Motor Function · SB-M + SB-C

Motor Function · SB-M + SB-C

Detect and track motor phenotypes across Parkinsonian Subtypes

Detect and track motor phenotypes across Parkinsonian Subtypes

Detect and track motor phenotypes across Parkinsonian Subtypes

SB-M detects declining speech motor control, hypokinetic dysarthria, and phonatory instability with greater precision than standard clinical scales. Paired with SB-C for cognitive tracking, a single brief speech protocol gives Parkinsonian trials, including MSA & PSP, an objective measure of both motor and cognitive function for trial inclusion, enrichment, and longitudinal progression.

At a glance

AUC 0.97

Speech features outperform UPDRS III for discriminating PD vs. MSA

0.84

Cohen’s d separating PD from healthy controls

<10 min

Speech task protocol

32

Languages available

At a glance

AUC 0.97

Speech features outperform UPDRS III for discriminating PD vs. MSA

0.84

Cohen’s d separating PD from healthy controls

<10 min

Speech task protocol

32

Languages available

PROBLEM

PROBLEM

PROBLEM

The Parkinsonian
Measurement Problem

3–6 months

Standard in-clinic intervals for data collection in PD trials (UPDRS). Daily occurring motor fluctuations and “on/off” medication states are missed.

90%+

of PD patients develop dysarthria over disease course

25–30%

of people with PD have MCI at diagnosis. Motor-only endpoints overlook early cognitive decline, creating risks in adherence and data integrity.

20–30%

Initial misclassification rate between typical PD and atypical syndromes (MSA, PSP)

SOLUTION

SOLUTION

A ~10-minute app assessment to provide increased granularity and sensitivity

A ~10-minute app assessment to provide increased granularity and sensitivity

A ~10-minute app assessment to provide increased granularity and sensitivity

Motor symptoms like imprecise articulation, reduced vocal loudness, changes in speech tempo, and breathy voice quality are core indicators of Parkinsonian progression. However, they are notoriously subjective to rate, fluctuate continuously, and are poorly captured by intermittent clinic visits alone.

ki:elements extracts acoustic, prosodic, and articulatory features from brief spoken tasks (sustained phonation, /pa-ta-ka/, reading) and returns an objective motor and intelligibility profile providing critical insight into disease progression for all Parkinsonian syndromes.

Assessment Protocol

01

Participant opens Mili

Any smartphone,

any location

Standard smartphone app or webpage. No special microphone, no wearable, no site visit required.

02

Standardized speech tasks administered

~10 minutes

Picture description, text reading, sustained phonation, and diadochokinesis are performed.

03

AI pipeline extracts intelligibility and acoustic features

Automated

The SIGMA pipeline generates the SB-M score alongside intelligibility and articulation subscores & pitch and loudness variability. No manual transcription required.

04

Score delivered via API or Mili dashboard

Same day

Structured output integrates into your EDC, CTMS, or study portal. Full audit trail. Longitudinal trajectory visualisation available for study teams to track disease state and drug response.

VALIDATION

VALIDATION

Built on rigorous clinical validation

DiMe V3 Aligned
DiMe V3 Aligned

SB-M validation follows the Digital Medicine Society’s V3 Framework, covering verification, analytical validation and clinical validation. A full validation package is available for regulatory submissions.

Multiple Languages
Multiple Languages

Validated in German, Czech, and Colombian Spanish typical and atypical PD cohorts. Supports multilingual, multinational clinical trial deployment.

Clinical Scale Anchors
Clinical Scale Anchors

SB-M and SB-C results are anchored to established clinical measures used in PD, PSP, and MSA trials: UPDRS III, PSPRS, UMSARS, SARS as well as MoCA and MMSE.

EVIDENCE

EVIDENCE

Key Publications in PD, PSP, MSA

View All Publications

View All Publications

View All Publications

Interested in
speech biomarkers for your Parkinsonian program?

Interested in
speech biomarkers for your Parkinsonian program?

Interested in
speech biomarkers for your Parkinsonian program?

Whether you are stratifying atypical neurodegenerative phenotypes or mapping real-world motor states, the ideal starting point is an exploratory technical alignment with our team.

Book a 30-minute feasibility call to talk through your study design and how the SB-M or the SB-C could fit.

Whether you are stratifying atypical neurodegenerative phenotypes or mapping real-world motor states, the ideal starting point is an exploratory technical alignment with our team.

Book a 30-minute feasibility call to talk through your study design and how the SB-M or the SB-C could fit.

Book Now

Book Now

Book Now

Book Now

Assessment Protocol