PSYCHIATRY

PSYCHIATRY

Objective speech features for MDD trials

Objective speech features for MDD trials

Objective speech features for MDD trials

Automated, scalable speech-based measures relevant to symptom fluctuation, including anhedonia and psychomotor retardation. Precision psychiatry delivered through a short spoken task.

ONGOING — We’re currently seeking partnership opportunities for additional validation in Major Depressive Disorder (MDD)

ONGOING — We’re currently seeking partnership opportunities for additional validation in Major Depressive Disorder (MDD)

At a glance

100+

features extracted per recording

~2 min

task protocol duration

PROBLEM

PROBLEM

PROBLEM

The MDD
Measurement Problem

280M

People affected by depression worldwide

High

Placebo response rates in clinical trials

Zero

Universally accepted objective biomarker for treatment response

Subjective

Inter-rater variability using traditional scales

Solution

Solution

Solution

Speech captures what rating scales miss

Speech captures what rating scales miss

Speech captures what rating scales miss

Beyond recall bias

Traditional depression rating scales (like the HAM-D or MADRS) heavily rely on patient recall and clinician interpretation, clouded by recall bias or subjective scoring. Analyzing acoustic properties, like speech rate, pause duration, and pitch variability, during a simple task provides objective measures without heavy burden.

Quantifies what’s hardest to measure

Psychomotor retardation and blunted affect are core diagnostic criteria for MDD, yet incredibly difficult to quantify precisely. ki:elements extracts over 100 acoustic, prosodic, and linguistic features from a brief speech sample — paving the way for automated tracking of subtle treatment responses.

EVIDENCE

EVIDENCE

Key Publications in Depression (MDD)

View All Publications

View All Publications

View All Publications

Interested in
speech biomarkers for your program?

Interested in
speech biomarkers for your program?

Interested in
speech biomarkers for your program?

Whether you’re planning a study or evaluating digital solutions for treatment-resistant depression, start with a 30-minute call to discuss it with our clinical team.

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