The ki:elements speech biomarker for
cognition
ki:e SB-C
Using speech to measure
cognitive changes
in clinical trials and research studiesA 10-minute phone call measures cognitive impairment automatically and remotely
The ki:elements speech biomarker for cognition measures cognitive function through speech. It is a composite score built up of automatically extracted speech features linked to three distinct domains:
learning and memory
executive function
processing speed
These features can be collected remotely or in-clinic, over the phone or via app. SB-C can be used out-of-the-box using our Mili system or be integrated into third party systems.
V3
guided
-–clinically
proven
Validation based on large cohorts across Europe following approved methodology from the V3 framework of the Digital Medicine Society (DiME)
Clear-cut differentiation among healthy controls, MCI and Dementia patients.
High correlation with clinical cognition rating anchors.
Strong links with AD cerebrospinal fluid markers, such as aBeta and pTau
Validation of the Remote Automated ki:e Speech Biomarker for Cognition in Mild Cognitive Impairment: Verification and Validation following DiME V3 Framework
Tröger et al. (2022) | doi: 10.1159/000526471
Use case scenario:
pre-screening
in Alzheimer’s DiseaseEnrollment as a key barrier for AD trials
80%
of trials fail to meet enrolment timelines
30%
of clinical trial’s timeline is spent on patient recruitment
$5.9B
spent annually on clinical trial recruitment
5%
or less of potential candidates enrolled in clinical trials
Using ki:e SB-C will significantly
reduce the number of candidates
invited to sites for screening andimprove successful screen-in rate.