Association of Speech and Language features with Biomarkers in Early Stage Alzheimer patients

Alexandra König1,2, Stefanie Köhler3, Johannes Tröger1, Elisa Mallick1, Nicklas Linz1, Josef Priller4-7, Markus Donix8,9, Jens Wiltfang10-12, Inga Zerr10,13, Emrah Düzel14-16, Annika Spottke17,18, Frederic Brosseron17, Michael Wagner17,19, Alfredo Ramirez17,19-22, Stefan Teipel3,23

1 ki:elements GmbH, Saarbrücken, Germany
2 Cobtek (Cognition-Behaviour-Technology), Université Côte d’Azur, Nice, France
3 Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Standort Rostock/Greifswald, Germany
4 Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, Germany
5 Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117 Berlin, Germany
6 School of Medicine, Technical University of Munich; Department of Psychiatry and Psychotherapy, Munich, Germany
7 University of Edinburgh and UK DRI, Edinburgh, UK
8 Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Dresden, Germany
9 Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
10 German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany
11 Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany
12 Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal
13 Department of Neurology, University Medical Center, Georg August University, Göttingen, Germany.
14 German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
15 Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.
16 Institute of Cognitive Neuroscience, University College London, London, UK.
17 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
18 Department of Neurology, University of Bonn, Bonn, Germany
19 Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
20 Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) University of Cologne, Germany.
21 Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany
22 Department of Psychiatry and Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, San Antonio, TX, USA
23 University Medical Center Rostock, Rostock, Germany

Presented at the 16th Clinical Trials on Alzheimer’s Disease conference (CTAD). Boston, 2023.